MyBioSource.com's Rat Anti-Heat Shock Factor 2 Antibody is a Rat monoclonal antibody. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Heat-shock factors(HSF1-4) play important roles in responding to the cellular stress signals, such as heat, heavy metals, and oxidative reagents and a wide variety of other stressors. HSF1 is activated by stress, whereas HSF2 lacks intrinsic stress responsiveness although the HSF2 expression changes which is coinciding with the functions of HSF2 in development. HSF1 and HSF2 form heterotrimers when bound to satellite III DNA in nuclear stress bodies, subnuclear structures in which HSF1 induces transcription. Upon stress, HSF2 DNA binding is HSF1 dependent. The heterotrimerization of HSF1 and HSF2 integrates transcriptional activation in response to distinct stress and developmental stimuli